Amifostine is a Nephro-Protectant in Patients Receiving Treatment with Cisplatin- Myth, Mystery or Matter-of-Fact?
Sin Sil Ha1, Kazi Rubaina1,2, Chung-Shien Lee1,2, Veena John2, Nagashree Seetharamu2*
1St. John’s University, College of Pharmacy and Health Sciences, Department of Clinical Health Professions, 8000 Utopia Parkway, Queens, NY 11439, USA.
2Division of Medical Oncology and Hematology, Northwell Health Cancer Institute, Donald & Barbara Zucker School of Medicine at Hofstra/Northwell, 450 Lakeville Road, Lake Success, NY 11042, USA
Despite reports of amifostine possibly protecting nephrotoxicity from cisplatin, it has not been recommended by any guidelines committees or routinely prescribed in clinical practice over the past decade. In this article, we review literature and guidelines regarding use of amifostine in oncology practice for protection against adverse effects from certain chemotherapeutic agents, in particular as a nephro-protectant in patients receiving cisplatin.View / Download Pdf
Commentary: Cannabinoids in Urology. Which Benign Conditions Might they be Appropriate to Treat: A Systematic Review
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Charles Taylor1*, Brian Birch1,2
1University of Southampton, Faculty of Medicine
2University Hospitals Southampton NHS FT, Southampton, UK
3Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Marta Ligero1, Kinga Bernatowicz1, Raquel Perez-Lopez1,2*
Radiomics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, 08035, Spain
Radiology Department, Vall d’Hebron University Hospital, Barcelona, 08035, Spain
*M.L. and K.B. are joint first authors. They have contributed equally to the literature systematic review and drafting of the manuscript.
The application of advanced computational analysis to medical imaging opens a plethora of opportunities in the field of radiology, allowing for more accurate tissue characterization and, eventually, advancing towards precision medicine through imaging biomarkers. In this review, we briefly introduce the methodology for radiomics analysis and the main challenges for implementation of radiomics-based tools in clinical practice. Based on systematic review of published studies, we also summarize here the main advances regarding CT-based radiomics applications in renal cancer with regards to tumor characterization (diagnosis, grading, prognosis), gene expression prediction (radiogenomics) and response evaluation.View / Download Pdf